| Mahmood Tarzi | (1919-1922) Minister of Foreign Affairs of the Kingdom of Amanullah Khan |
| Mohammad Wali Khan Darwazi | (1922-1924) Minister of Foreign Affairs of the Kingdom of Amanullah Khan |
| Ghulam Sediq Khan Charkhi | (1924-1927) Minister of Foreign Affairs of the Kingdom of Amanullah Khan |
Faiz Mohammad Khan Zekriya | (1929-1939)Minister of Foreign Affairs of the Kingdom of Mohammad Nader Shah and the Kingdom of Mohammad Zaher Shah |
| Ali Mohammad Khan | (1946-1952) Minister of Foreign Affairs of the Kingdom of Mohammad Zaher Shah |
| Sultan Ahmad Khan | (1952-1953) Minister of Foreign Affairs of the Kingdom of Mohammad Zaher Shah |
Sardar Mohammad Naim Khan | (1953-1955)Minister of Foreign Affairs and Deputy Prime Minister of the Kingdom of Mohammad Zaher Shah |
Dr. Mohammad Yosuf Khan | (1963-1965)Minister of Foreign Affairs and Prime Minister of the Kingdom of Mohammad Zaher Shah |
Noor Ahmad Etemadi | (1965-1967) Minister of Foreign Affairs and (1967-1971) Minister of Foreign Affairs and Prime Minister of the Kingdom of Mohammad Zaher Shah |
Mohammad Mosa Shafiq | (1971-1972 and 1972-1973) Minister of Foreign Affairs and Prime Minister of the Kingdom of Mohammad Zaher Shah |
Sardar Mohammad Dawood Khan | (1973-1977) Minister of Foreign Affairs and President of the Republic of Afghanistan |
Wahid Abdullah | (1977-1978) Minister of Foreign Affairs of the Republic of Afghanistan (President Sardar Mohammad Dawood Khan) |
Hafizullah Amin | (1978-1979) Minister of Foreign Affairs and Deputy Prime Minister (President Noor Mohammad Taraki) |
| Dr. Shah Wali Khan | (Late 1979-Early 1980) Minister of Foreign Affairs (President Hafizullah Amin) |
| Shah Mohammad Dost | (1980-1986) Minister of Foreign Affairs (President Babrak Karmal) |
| Abdul Wakil | (1986-1992) Minister of Foreign Affairs (President Dr. Najibullah) |
Sayed Salman Gailani | (1992-1993) Minister of Foreign Affairs of the Interim Government of Professor Hazrat Sebghatullah Mujaddedi |
Hedayat Amin Arsala | (1993-1994) Minister of Foreign Affairs of the Islamic State of Afghanistan (Professor Burhanuddin Rabbani) |
Abdul Rahim Ghafoorzai | (1996) Minister of Foreign Affairs of Islamic State of Afghanistan (Professor Burhanuddin Rabbani) |
Dr. Abdullah Abdullah | (1998-2006) Minister of Foreign Affairs of the Interim Administration, the Transitional Government and the Islamic Republic of Afghanistan (President Hamid Karzai) |
Dr. Rangin Dadfar Spanta | (April 20, 2006-January 17, 2010) Minister of Foreign Affairs of the Islamic Republic of Afghanistan (President Hamid Karzai) |
Dr. Zalmai Rassoul | (January 23, 2010-October 05, 2013) Minister of Foreign Affairs of the Islamic Republic of Afghanistan (President Hamid Karzai) |
| Zarar Ahmad Osmani | (October 28, 2013-December 06, 2014) Minister of Foreign Affairs of the Islamic Republic of Afghanistan (President Hamid Karzai) |
| Salahuddin Rabbani | (February 2015 – October 2019) Minister of Foreign Affairs of the Islamic Republic of Afghanistan (President Ashraf Ghani) |
| Mohammad Hanif Atmar | Current |